Lewis Acid‐Catalyzed Strain‐Enabled (3+3) Annulation of Bicyclo[1.1.0]Butanes With Indolylalcohols: Synthesis of Indole‐Fused Aza‐Bicyclo[3.1.1]Heptanes
Mainak Dey, Tuhin Subhra Das Mahapatra, Pragya Sharma, Manoj V Mane, Chinmoy Kumar Hazra · 2026
Read Lewis Acid‐Catalyzed Strain‐Enabled (3+3) Annulation of Bicyclo[1.1.0]Butanes With Indolylalcohols: Synthesis of Indole‐Fused Aza‐Bicyclo[3.1.1]Heptanes by Mainak Dey, Tuhin Subhra Das Mahapatra, Pragya Sharma, Manoj V Mane, Chinmoy Kumar Hazra (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13676991.txt.
Description
Mainak Dey and four co-authors report a strain-driven reaction in two thousand twenty-six that builds complex ring systems. Bicyclobutanes are tiny, highly strained rings prized as building blocks. Joining them with indole alcohols could yield rigid frameworks of interest for drug design.
A Lewis acid catalyst drives a formal three-plus-three ring-forming reaction between the two partners. The products are indole-fused bicyclic heptanes rich in three-dimensional character. The reaction runs under mild conditions and tolerates many functional groups. Control tests and calculations support a stepwise path: the acid activates the alcohol, strain release forges a carbon bond, and a ring expansion closes the nitrogen bond. The method gives fast access to complex scaffolds.
Catalog record
| CREATOR | Mainak Dey, Tuhin Subhra Das Mahapatra, Pragya Sharma, Manoj V Mane, Chinmoy Kumar Hazra |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |