Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He · 2026
Read Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation by Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13676988.txt.
Description
Chi Zhan and co-authors identify a guard protein in bone blood vessel cells that holds back osteoporosis, in work from 2026. Bone loss with age involves worn vessel niches, but how redox faults in those cells drive loss was unclear. The guard is a mitochondrial protein that mops up reactive oxygen.
The protein ran low in aging vessel cells of bone. Mice lacking it in those cells lost bone faster, with less bone building and more bone eating. The team traced the chain: the guard holds a switch protein at the cell's power units, and when the hold breaks, the switch turns on a signal that feeds bone-eating cells. Blocking that signal or restoring the guard eased bone loss in mice.
Catalog record
| CREATOR | Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |