Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu · 2026
Read Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV by Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13676815.txt.
Description
Karthick Chennakesavan and co-authors study how HIV harms the brain, using lab-grown mini-brains called cerebral organoids, in a 2026 paper. Brain problems remain common in people with HIV even when drugs keep the virus in check. The organoids, which include the brain's immune cells, model the human brain in three dimensions.
Infected immune cells in the organoids switched on and set off chain reactions of inflammation through several linked pathways. One signal, IL-17A, sat near the center of the damage, tied to worn synapses and cell stress. Standard HIV drug treatment calmed much of this activity, repaired energy-making in cells, and restored synapse genes. The team checked key findings in monkey brain tissue as well. They name the pathways as targets for future drugs against HIV brain disease.
Catalog record
| CREATOR | Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 100 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |