A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu · 2026
Read A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle by Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13676814.txt.
Description
Xinqiang Yin and co-authors report finding a tiny new protein hidden inside a textbook energy pathway. The pathway, the TCA cycle, is how cells burn fuel to make ATP, their energy currency. Textbooks treat its enzyme cast as complete. The team found a twenty-nine-unit peptide, built from a small overlooked gene segment inside another gene in mice.
The peptide, named APPM, sits in the mitochondria, the cell's power stations, and binds a key enzyme complex of the cycle. By gripping that complex, it tunes how much energy-carrying NADH and ATP the cycle produces. Giving the peptide to mice raised ATP levels, and in mice with heart failure it restored heart function better than a standard comparison drug. The authors present APPM as the first known micropeptide regulator of this complex.
Catalog record
| CREATOR | Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |