Response to Khodamoradi: Methodological clarifications regarding NanOx predictions in helium SOBP

Thomas Berger, Gersende Alphonse, Mario Alcocer-Avila, Caterina Monini, Charbel Koumeir, Claire Rodriguez-Lafrasse, Nicolas Varmenot, Vincent Métivier, Ferid Haddad, Jean Michel Létang, Étienne Testa · 2026

Read Response to Khodamoradi: Methodological clarifications regarding NanOx predictions in helium SOBP by Thomas Berger, Gersende Alphonse, Mario Alcocer-Avila, Caterina Monini, Charbel Koumeir, Claire Rodriguez-Lafrasse, Nicolas Varmenot, Vincent Métivier, Ferid Haddad, Jean Michel Létang, Étienne Testa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13676694.txt.

Description

Berger and co-authors wrote a reply, published in 2026, to a critic of their model of cell survival under particle radiation. The model predicts how many cells survive beams used in cancer treatment. A critic had charged that the team tuned the model on one cell line and then claimed success on the same cells. The reply says this charge rests on a misreading of the methods.

The authors explain that survival depends on the beam as well as the cells. They tuned the model with data from proton and carbon beams. They then tested it on helium beams, a different beam type, in the same cell line. That makes the test a real check, not a repeat of the tuning data. The reply answers the critic's second concern in the same way, point by point. It aims to clear up how the model's tests were set up.

Catalog record

CREATORThomas Berger, Gersende Alphonse, Mario Alcocer-Avila, Caterina Monini, Charbel Koumeir, Claire Rodriguez-Lafrasse, Nicolas Varmenot, Vincent Métivier, Ferid Haddad, Jean Michel Létang, Étienne Testa
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE5 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13676694

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