IL-1β/IL-6 inflammatory crosstalk drives DNA methylation and histone remodeling associated with cytokine induced senescence in luminal breast cancer
Satyajit Dey Pereira, Kanaka Sai Ram Padam, Padival Shruptha, Aditi Atreya, Manjunath B Joshi, Kapaettu Satyamoorthy · 2026
Read IL-1β/IL-6 inflammatory crosstalk drives DNA methylation and histone remodeling associated with cytokine induced senescence in luminal breast cancer by Satyajit Dey Pereira, Kanaka Sai Ram Padam, Padival Shruptha, Aditi Atreya, Manjunath B Joshi, Kapaettu Satyamoorthy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13676678.txt.
Description
Satyajit Dey Pereira and five co-authors trace how two inflammatory signals drive aging-like arrest in breast cancer cells. Their twenty twenty-six article studies luminal breast cancer, a common hormone-sensitive type. Chronic inflammation can both halt tumor growth and feed it, a paradox the team sets out to unpick.
Working with MCF-7 cells, they show the signals IL-1 beta and IL-6 form a two-way circuit. The first signal pushes cells into senescence: they stop dividing, show aging markers, and build up reactive oxygen, but do not die. It also raises the enzymes that tag DNA with methylation and reshapes histone marks at key genes. Blocking the receptors breaks the loop, which maps the circuit's wiring.
Catalog record
| CREATOR | Satyajit Dey Pereira, Kanaka Sai Ram Padam, Padival Shruptha, Aditi Atreya, Manjunath B Joshi, Kapaettu Satyamoorthy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |