Targeted pathway mining reveals novel modified hexapeptides from the demiguisin family
Tanya Decker, Marie Dayras, Lena Schweizer, Sari Rasheed, Franziska Fries, Bulisa Iova, Kasun H Bodawatta, Knud Andreas Jønsson, Rolf Müller, Christine Beemelmanns · 2026
Read Targeted pathway mining reveals novel modified hexapeptides from the demiguisin family by Tanya Decker, Marie Dayras, Lena Schweizer, Sari Rasheed, Franziska Fries, Bulisa Iova, Kasun H Bodawatta, Knud Andreas Jønsson, Rolf Müller, Christine Beemelmanns (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13676617.txt.
Description
Tanya Decker and co-authors report new members of a family of natural compounds called demiguisins in a 2026 paper. The family came from a germ found on a toxic bird, and its members are short chains built with an unusual acid building block. The team used the gene cluster that makes the first known member as a search probe in other germs.
The search found just one more producer, a soil germ with a nearly matching gene cluster. Grown under feather-like conditions, the two germs made some shared products, and the soil germ yielded five new variants. Two of the new compounds killed a bird germ that causes disease and also acted against the tuberculosis germ.
Catalog record
| CREATOR | Tanya Decker, Marie Dayras, Lena Schweizer, Sari Rasheed, Franziska Fries, Bulisa Iova, Kasun H Bodawatta, Knud Andreas Jønsson, Rolf Müller, Christine Beemelmanns |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |