Timing matters: a life-course review of midlife type 2 diabetes, exposure duration, and late-life dementia risk
Mrityunjay Sivakumar, Chakravarthy Marx Sadacharan · 2026
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Description
Sivakumar and Sadacharan wrote a review, published in 2026, on how the timing of type 2 diabetes shapes dementia risk in later life. Diabetes in midlife is known to raise the chance of memory loss decades later. The review asks finer questions. Does the age when diabetes starts matter? Does the number of years lived with it matter? Do swings in blood sugar add their own harm?
The authors gathered past studies using set search and selection rules. Their reading says midlife onset and long exposure carry the greatest risk. Years of high or unstable blood sugar seem to damage the brain through vessel and cell pathways over time. Diabetes that starts late in life shows a weaker and less clear link. The review argues that prevention should focus on midlife, when action has the longest time to pay off.
Catalog record
| CREATOR | Mrityunjay Sivakumar, Chakravarthy Marx Sadacharan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |