Toward Cell‐Specific Molecular MRI: Modulating Chemical Exchange Saturation Transfer Contrast With Manganese
Eleonora Cavallari, Valeria Bitonto, Morgana Giachello, Angelo Bifone · 2026
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Description
Cavallari, Bitonto, Giachello, and Bifone add manganese to a molecular MRI method so the signal can be split by cell type. The base method senses faint metabolite pools but mixes contributions from neurons, support cells, and structural material. Manganese slips into active excitable cells through calcium channels and shortens a relaxation time there, dimming their share of the signal.
Comparing spectra with and without manganese isolates the sensitive share. In the cerebellum of living chick embryos, manganese cut the relaxation time by about twenty-eight percent and reshaped the spectrum at spots matching neuron-linked pools. Their 2026 paper presents the trick, MangaCEST, as a route to cell-weighted molecular imaging.
Catalog record
| CREATOR | Eleonora Cavallari, Valeria Bitonto, Morgana Giachello, Angelo Bifone |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |