Structural Snapshots of F1 ‐ATPase Catalysis in Drug Resistant Acinetobacter baumannii Reveal Novel Therapeutic Targets
Khoa C M Le, Jan K Marzinek, Vikneswaran Mathiyazakan, Peter J Bond, Gerhard Grüber · 2026
Read Structural Snapshots of F1 ‐ATPase Catalysis in Drug Resistant Acinetobacter baumannii Reveal Novel Therapeutic Targets by Khoa C M Le, Jan K Marzinek, Vikneswaran Mathiyazakan, Peter J Bond, Gerhard Grüber (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13676158.txt.
Description
Khoa Le and co-authors present, in a 2026 study, snapshots of the energy-making machine inside a drug-resistant hospital germ. The germ resists many drugs, partly by pumping them out using cell energy. It cannot ferment, so it leans fully on this energy pathway.
Using a freezing microscope method, the team caught the machine's head section mid-action as it built ATP, the cell's energy coin. The parts twist and shift together, and new energy coins form as the motion completes. Computer simulations backed up and extended what the images showed. Seeing the machine move points to fresh spots where a drug could jam it. That offers a new angle against a germ that defeats many current drugs.
Catalog record
| CREATOR | Khoa C M Le, Jan K Marzinek, Vikneswaran Mathiyazakan, Peter J Bond, Gerhard Grüber |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |