Selective mGlu1 Receptor Activation Restores Cortical Inhibitory Tone and Improves Cognitive Performance in a Subchronic Phencyclidine NMDA Hypofunction Model
Deborah J Luessen, Isabel M Gallinger, Brenna Wolfe, Mac J Meadows, Michael Z Leonard, Geanne A Freitas, Craig W Lindsley, Erin S Calipari, Colleen M Niswender, P Jeffrey Conn · 2026
Read Selective mGlu1 Receptor Activation Restores Cortical Inhibitory Tone and Improves Cognitive Performance in a Subchronic Phencyclidine NMDA Hypofunction Model by Deborah J Luessen, Isabel M Gallinger, Brenna Wolfe, Mac J Meadows, Michael Z Leonard, Geanne A Freitas, Craig W Lindsley, Erin S Calipari, Colleen M Niswender, P Jeffrey Conn (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13676117.txt.
Description
Deborah Luessen and co-authors report a 2026 mouse study tied to the thinking problems seen in schizophrenia. Current drugs do little for those symptoms, which may stem from weak calming signals in the front part of the brain. The team tested whether turning on one receptor type could restore that balance.
The work used mice given a drug that blocks a key brain receptor, a model of the illness. Compounds that boost the target receptor were tested, along with mice bred to lack it in select cells. The title reports that this approach restored calming tone in the cortex and improved performance on thinking tasks. The findings point to a possible new drug path, though all tests so far are in mice.
Catalog record
| CREATOR | Deborah J Luessen, Isabel M Gallinger, Brenna Wolfe, Mac J Meadows, Michael Z Leonard, Geanne A Freitas, Craig W Lindsley, Erin S Calipari, Colleen M Niswender, P Jeffrey Conn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |