PINK1-mediated mitophagy supports lung cancer initiation and limits the efficacy of KRAS-targeted therapy
Diogo Gonçalves, Emma Guilbaud, Léa Di Mascio, Camille Guerrier, Linda Mejri, Sonia Núñez-Vázquez, Lucie Levasseur, Rachel Paul, Corinne Menigot, Christophe Bontoux, Guylène Rignol, Véronique Hofman, Paul Hofman, Marin Truchi, Bernard Mari, Laurent Yvan-Charvet, Johanna Chiche, Sandrine Marchetti, J · 2026
Read PINK1-mediated mitophagy supports lung cancer initiation and limits the efficacy of KRAS-targeted therapy by Diogo Gonçalves, Emma Guilbaud, Léa Di Mascio, Camille Guerrier, Linda Mejri, Sonia Núñez-Vázquez, Lucie Levasseur, Rachel Paul, Corinne Menigot, Christophe Bontoux, Guylène Rignol, Véronique Hofman, Paul Hofman, Marin Truchi, Bernard Mari, Laurent Yvan-Charvet, Johanna Chiche, Sandrine Marchetti, J (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13674508.txt.
Description
Diogo Gonçalves and co-authors report, in a 2026 study, that a cell cleanup process helps lung cancer start and blunts targeted drugs. The process, called mitophagy, clears worn-out energy units inside cells. Its role in early lung tumors was poorly known.
Using human tumor samples and reporter mice, the team watched the process live as tumors formed. Activity of the key protein was high in human tumors and rose from the earliest stages. Blocking that protein slowed the change of normal cells into cancer cells. The work suggests tumors lean on cleanup to survive their first steps. It also hints that blocking cleanup could restore the power of drugs aimed at a common cancer gene.
Catalog record
| CREATOR | Diogo Gonçalves, Emma Guilbaud, Léa Di Mascio, Camille Guerrier, Linda Mejri, Sonia Núñez-Vázquez, Lucie Levasseur, Rachel Paul, Corinne Menigot, Christophe Bontoux, Guylène Rignol, Véronique Hofman, Paul Hofman, Marin Truchi, Bernard Mari, Laurent Yvan-Charvet, Johanna Chiche, Sandrine Marchetti, J |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |