Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control
Nila K. van Overbeek, Linda Clijsters, Martina Wirth, Ilona J. de Graaf, Klaas de Lint, Sidrit Uruci, Amina F. A. S. Teunisse, Vyacheslav Akimov, Arnoud H. de Ru, Maja Vukic, Idil Kirdök, Lucia Daxinger, Peter A. van Veelen, Blagoy Blagoev, Martijn S. Luijsterburg, Rob M. F. Wolthuis, Ilana Berlin, · 2026
Read Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control by Nila K. van Overbeek, Linda Clijsters, Martina Wirth, Ilona J. de Graaf, Klaas de Lint, Sidrit Uruci, Amina F. A. S. Teunisse, Vyacheslav Akimov, Arnoud H. de Ru, Maja Vukic, Idil Kirdök, Lucia Daxinger, Peter A. van Veelen, Blagoy Blagoev, Martijn S. Luijsterburg, Rob M. F. Wolthuis, Ilana Berlin, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13674506.txt.
Description
A large research team reports, in a 2026 study, a gene screen that maps how cells survive when their protein-tagging system is blocked. The tagging system marks worn proteins for disposal and keeps cell division in order. Blocking its first step stresses cancer cells in useful ways.
The team switched off genes one by one across the genome while a blocking drug was present. Loss of 239 genes made cells far more sensitive to the block. Follow-up work singled out a partner pair of proteins that guard the cell's DNA packaging. When that guard fails, tagged proteins pile up where they can do harm. The findings name new pressure points where cancer drugs might push next.
Catalog record
| CREATOR | Nila K. van Overbeek, Linda Clijsters, Martina Wirth, Ilona J. de Graaf, Klaas de Lint, Sidrit Uruci, Amina F. A. S. Teunisse, Vyacheslav Akimov, Arnoud H. de Ru, Maja Vukic, Idil Kirdök, Lucia Daxinger, Peter A. van Veelen, Blagoy Blagoev, Martijn S. Luijsterburg, Rob M. F. Wolthuis, Ilana Berlin, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |