Mechanisms regulating cerebral perfusion during running exercise: Influence of foot strike‐induced pulsatility oscillations, CO2 reactivity and BP
Lydia L. Simpson, Dean R. Perkins, Connor A. Howe, Christina D. Bruce, William K. Cornwell, Justin S. Lawley · 2026
Read Mechanisms regulating cerebral perfusion during running exercise: Influence of foot strike‐induced pulsatility oscillations, CO2 reactivity and BP by Lydia L. Simpson, Dean R. Perkins, Connor A. Howe, Christina D. Bruce, William K. Cornwell, Justin S. Lawley (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13674218.txt.
Description
Lydia Simpson and co-authors studied why brain blood flow keeps rising during hard running instead of falling as it does in cycling, in work published in 2026. Forty three runners had brain artery speed measured through a step up test. Flow climbed to peak effort even as exhaled carbon dioxide dropped.
A special stepping pattern that removed foot strike pulses did not change average flow, which rules out impact pulses as the driver. The vessels' response to low carbon dioxide weakened during running in step with rising blood pressure. When pressure was matched, running and cycling looked the same. The authors conclude pressure, not exercise type, sets the brain flow response.
Catalog record
| CREATOR | Lydia L. Simpson, Dean R. Perkins, Connor A. Howe, Christina D. Bruce, William K. Cornwell, Justin S. Lawley |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |