PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu · 2026
Read PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing by Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13674132.txt.
Description
Jiewen Liao and ten co-authors built a microneedle patch that calms inflammation to heal diabetic wounds, in a 2026 study. Slow healing in diabetes involves immune cells stuck in an attack state. A signal protein drives that state, the team shows. Stressed skin cells then age early under the resulting inflammation. A plant compound blocks the driver signal.
The compound was packed into tiny silica carriers. Membranes from immune cells coated the carriers to home them to their targets. The carriers sit inside a hydrogel formed into microneedles. The patch releases drug in a controlled way and resists germs. It also soaks up harmful oxygen species. In animals, wounds closed faster with the patch. New vessels and collagen grew better, and cell aging fell. The authors propose the patch for clinical development.
Catalog record
| CREATOR | Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |