Recent advances in coarse-grained simulations of nucleic acid condensation
Jessica Fong Ng, Shanlong Li, Jianhan Chen · 2026
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Description
Cells organize much of their chemistry in droplets called condensates, which form when molecules such as DNA and RNA separate from the surrounding fluid. Jessica Fong Ng, Shanlong Li, and Jianhan Chen review computer simulations of these droplets in a 2026 paper. They focus on coarse-grained models, which simplify molecules into beads so that large systems can be simulated.
The review surveys the main modeling frameworks and checks them against experiments. Studies show that interactions between the bases of nucleic acids drive much of the clumping when one kind of molecule condenses alone. The level of detail a model keeps decides which behaviors it can even show. The authors map where the tools fall short, especially for the mixed, crowded droplets found in living cells.
Catalog record
| CREATOR | Jessica Fong Ng, Shanlong Li, Jianhan Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |