Mechanisms of deoxysphinganine cytotoxicity in lymphoma cells
Fabiola N Velazquez, Karissa J Lopez, Bahman Khalvatifahlylani, Daniel Canals, Yusuf A Hannun · 2026
Read Mechanisms of deoxysphinganine cytotoxicity in lymphoma cells by Fabiola N Velazquez, Karissa J Lopez, Bahman Khalvatifahlylani, Daniel Canals, Yusuf A Hannun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13672851.txt.
Description
Some fatty molecules that build cell membranes can also kill cells when they take an unusual form. A 2026 study by Fabiola Velazquez and co-authors examines one such molecule, deoxysphinganine, in lymphoma cells. The team wanted to learn how the molecule kills and whether that killing could be turned against cancer.
The molecule killed lymphoma cell lines far more strongly than it harmed normal human T cells, which it only slowed. Blocking one enzyme stopped the killing, showing that the cell must first convert the molecule into related fats. Death ran through the mitochondria, the cell's energy centers, while a parallel stress response in another compartment proved not to be required. The gap between cancer and normal cells marks a possible drug target.
Catalog record
| CREATOR | Fabiola N Velazquez, Karissa J Lopez, Bahman Khalvatifahlylani, Daniel Canals, Yusuf A Hannun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |