Symptom improvement with dosing above 9 g of low-sodium oxybate: effectiveness and safety in participants with narcolepsy in the DUET study
Jerald H. Simmons, Logan D. Schneider, Chad M. Ruoff, David T. Plante, Deborah A. Nichols, Teresa L. Steininger, Marisa Whalen, M. Todd Kirby, Jing Dai, Alyssa Cairns, Richard K. Bogan · 2026
Read Symptom improvement with dosing above 9 g of low-sodium oxybate: effectiveness and safety in participants with narcolepsy in the DUET study by Jerald H. Simmons, Logan D. Schneider, Chad M. Ruoff, David T. Plante, Deborah A. Nichols, Teresa L. Steininger, Marisa Whalen, M. Todd Kirby, Jing Dai, Alyssa Cairns, Richard K. Bogan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13672759.txt.
Description
Jerald Simmons and co-authors tested in 2026 whether narcolepsy patients gain more from a nightly sleep drug dose above the approved ceiling. Forty-eight participants first stabilized on nine grams of low-sodium oxybate, then titrated up to as much as twelve. Sleepiness, disease severity, and breathing during sleep were tracked through the steps.
At the higher dose, sleepiness scores and severity scores improved clearly in both narcolepsy types. Fewer patients rated their disease severe, and over ninety percent felt improved overall. Breathing measures during sleep stayed flat, and side effects matched the drug's known list, led by nausea. The authors back individualized dosing above nine grams for patients who need it. The open-label design tempers the claim, and they say so.
Catalog record
| CREATOR | Jerald H. Simmons, Logan D. Schneider, Chad M. Ruoff, David T. Plante, Deborah A. Nichols, Teresa L. Steininger, Marisa Whalen, M. Todd Kirby, Jing Dai, Alyssa Cairns, Richard K. Bogan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |