Middle Cerebral Artery Occlusion-induced Deficits in Fine Skilled Motor Movement and Its Recovery Following Combined Treatment with Sodium Valproate and CIMT
Rini PG, Yoganarasimha Doreswamy, Laxmi TR · 2026
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Description
Rini and co-authors test a drug-plus-therapy pairing for fine hand skill after stroke in rats. Their twenty twenty-six study blocks the middle cerebral artery for one hour to mimic human stroke. Valproate, a known drug, has shown protective effects on injured brain tissue.
Treated rats got the drug twice daily for seven days, then constraint therapy forced use of the weak paw. The combo was weighed against each part alone. Brain wiring changes, local and across hemispheres, were tracked beside movement scores. Rehab drugs are scarce; proof that a cheap old drug boosts therapy gains would matter far beyond this lab model.
Catalog record
| CREATOR | Rini PG, Yoganarasimha Doreswamy, Laxmi TR |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |