Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang · 2026
Read Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair by Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13672688.txt.
Description
Bone loss makes jaw defects slow to heal, partly because stem cells in the bone marrow work poorly in that setting. Xiayue Jin and co-authors build a treatment aimed at those cells in a 2026 paper. Their injectable gel carries tiny metal-framework particles doped with manganese and zinc into the defect.
In the lab, stem cells from osteoporotic bone formed less new bone and carried high levels of damaging reactive oxygen species. The gel lowered that stress and improved the health of the cells' mitochondria, their energy centers, which were splitting apart too often. A signaling protein rose while the splitting driver fell. In osteoporotic mice, the gel sped repair of tooth sockets. The work links fixing cell energy problems to better bone healing.
Catalog record
| CREATOR | Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |