The BRCA1 coiled-coil domain is dispensable for suppression of tandem duplications and tolerance of FANCM loss
Namrata M Nilavar, Alberto Marin-Gonzalez, Francesca Menghi, Daniel Nguyen, Nicholas A Willis, Ellen Wientjens, Bing Xia, Jos Jonkers, Edison T Liu, Ralph Scully · 2026
Read The BRCA1 coiled-coil domain is dispensable for suppression of tandem duplications and tolerance of FANCM loss by Namrata M Nilavar, Alberto Marin-Gonzalez, Francesca Menghi, Daniel Nguyen, Nicholas A Willis, Ellen Wientjens, Bing Xia, Jos Jonkers, Edison T Liu, Ralph Scully (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13672311.txt.
Description
Namrata Nilavar leads a team on a BRCA1 domain and tandem duplications. Their study from twenty twenty-six deals with a coiled coil domain. BRCA1 linked cancers hold many small tandem duplications.
Such copies form in stem cells that lack a big BRCA1 part. Mutants of the coil domain lose some repair jobs. Yet they keep the power to suppress those duplications. That held in both cell tests and a mouse tumor model. Those cancers may thus grow by a distinct path. Loss of a partner gene even helped mutant cells grow.
Catalog record
| CREATOR | Namrata M Nilavar, Alberto Marin-Gonzalez, Francesca Menghi, Daniel Nguyen, Nicholas A Willis, Ellen Wientjens, Bing Xia, Jos Jonkers, Edison T Liu, Ralph Scully |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |