Comparative effectiveness of amlodipine versus nifedipine prescribed at discharge in patients with ischemic stroke or transient ischemic attack: A nationwide 5-year follow-up registry study

Description

Xinya Li and co-authors compare two blood pressure drugs in stroke survivors over five years, in a 2026 registry study. Both drugs widen vessels by blocking calcium channels. They are the commonest choices after ischemic stroke or mini-stroke. Direct comparison evidence was scarce. The team drew on a national Chinese stroke registry. Patients discharged on either drug were followed. Weighting balanced the groups at baseline.

Nearly twenty-nine hundred patients qualified. After weighting, the amlodipine group fared better at five years. Their disability scores sat lower on the standard scale. The odds favored amlodipine clearly. Fewer of its users had any lasting disability. Sensitivity checks agreed with the main result. Limits include the observational design and follow-up losses. The authors say the gap is large enough to matter for prescribing. A randomized trial could settle the question.

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Source: https://europepmc.org/articles/PMC13671639