Streptococcus pyogenes carriage is associated with distinct in vivo transcriptional states but not carrier-specific genotypes
Nicholas Faiola, Jason M Wood, Nicole Casab, May Xu, Kevin Quirk, Christopher Thomas, Eliza Klos, Jordan Thesier, Mitchell Waldran, Mark Maienschein-Cline, Michael J Federle, Gregory P DeMuri, Ellen R Wald, Laura C Cook · 2026
Read Streptococcus pyogenes carriage is associated with distinct in vivo transcriptional states but not carrier-specific genotypes by Nicholas Faiola, Jason M Wood, Nicole Casab, May Xu, Kevin Quirk, Christopher Thomas, Eliza Klos, Jordan Thesier, Mitchell Waldran, Mark Maienschein-Cline, Michael J Federle, Gregory P DeMuri, Ellen R Wald, Laura C Cook (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13671490.txt.
Description
Faiola and co-authors study silent carriage of Streptococcus pyogenes, also called group A Streptococcus. Their paper deals with a major human pathogen whose carrier state clouds care and drives spread.
Samples were taken from people before and after treatment for acute strep throat. Selected isolates had whole-genome and RNA sequencing, giving gene activity maps straight from human throat swabs. Genomic analysis found no steady carrier-specific genotypes. Lab assays also showed no major gaps in biofilm formation or how drugs affect them between carrier and non-carrier samples. But gene action in the body did split into distinct states tied to carriage.
Catalog record
| CREATOR | Nicholas Faiola, Jason M Wood, Nicole Casab, May Xu, Kevin Quirk, Christopher Thomas, Eliza Klos, Jordan Thesier, Mitchell Waldran, Mark Maienschein-Cline, Michael J Federle, Gregory P DeMuri, Ellen R Wald, Laura C Cook |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |