Severity-dependent and sex-biased dysregulation of A-to-I RNA editing in COVID-19 reveals CTSS as a key regulatory target
Jing-Yuan Wang, Ya-Di Zhao, Li-Ping Wang, Yu-Qing Ren, Jia-Nuo Li, Teng Wang, Hua-Kang Zhang, Feng Zhu, Jian-Huan Chen, Yun-Yun Jin · 2026
Read Severity-dependent and sex-biased dysregulation of A-to-I RNA editing in COVID-19 reveals CTSS as a key regulatory target by Jing-Yuan Wang, Ya-Di Zhao, Li-Ping Wang, Yu-Qing Ren, Jia-Nuo Li, Teng Wang, Hua-Kang Zhang, Feng Zhu, Jian-Huan Chen, Yun-Yun Jin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13671454.txt.
Description
Jing-Yuan Wang and co-authors map how RNA editing shifts with COVID-19 severity and sex, in a 2026 study of 126 blood samples. A-to-I editing, run by enzymes called ADARs, helps tune the innate immune response to viruses. The team profiled editing across controls and patients of different severity and found 1,466 changed sites in 514 genes tied to outcomes.
Editing enzyme levels rose in patients overall but fell sharply in intensive care patients, far more in men than in women. One gene, CTSS, stood out: extra editing in its tail region steadied its message in the sickest patients. The authors propose that editing mark as a way to sort patients by risk.
Catalog record
| CREATOR | Jing-Yuan Wang, Ya-Di Zhao, Li-Ping Wang, Yu-Qing Ren, Jia-Nuo Li, Teng Wang, Hua-Kang Zhang, Feng Zhu, Jian-Huan Chen, Yun-Yun Jin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |