Estradiol-associated extracellular signaling in the human breast in vivo identifies mast cells as tumor-supportive stromal mediators
Annelie Abrahamsson, Xingyue Wang, Wen Zhong, Charlotta Dabrosin · 2026
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Description
Annelie Abrahamsson and co-authors sample proteins from live human breast tissue to trace how a female hormone shapes tumor support. Their paper from 2026 uses a fine tube method to draw fluid from normal breast and from breast cancers. In all, more than a thousand proteins were measured.
A set of one hundred fifty proteins tracked local hormone levels in the tissue. Several of them tied to mast cells, a type of immune cell in tissue. Cancers of the hormone driven type had more of one mast cell signal and more mast cells, which went with worse survival. In lab and animal tests, the hormone woke mast cells fast, and an allergy drug blocked that effect.
Catalog record
| CREATOR | Annelie Abrahamsson, Xingyue Wang, Wen Zhong, Charlotta Dabrosin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |