Pstpip2-deficient mouse models in SAPHO syndrome research: Utility, mechanistic insights, and translational limitations
Yu Wang, Bowen Feng, Yunuo Wang, Yi Wang, Yingai Xu, Mengjiao Gu, Yuanhao Wu · 2026
Read Pstpip2-deficient mouse models in SAPHO syndrome research: Utility, mechanistic insights, and translational limitations by Yu Wang, Bowen Feng, Yunuo Wang, Yi Wang, Yingai Xu, Mengjiao Gu, Yuanhao Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13671040.txt.
Description
Yu Wang and co-authors weigh a mouse model for a rare inflammatory syndrome in a 2026 review. SAPHO syndrome mixes skin pustules with inflamed, overgrown bone, and its cause is unsettled. Mice missing the Pstpip2 gene develop sterile bone inflammation that resembles it.
The review collects what those mice teach: runaway neutrophils, excess IL-1 signaling, and bone cells tipped toward destruction and odd regrowth. Skin and blood signs vary by model. Breeding, strain background, diet, and gut microbes all sway how sick the mice get. That instability limits translation to patients. Still, the model remains the main test bed for candidate drugs and mechanisms.
Catalog record
| CREATOR | Yu Wang, Bowen Feng, Yunuo Wang, Yi Wang, Yingai Xu, Mengjiao Gu, Yuanhao Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |