B1486 is a highly potent VprBP inhibitor capable of blocking osteoclast differentiation and bone resorption
Sungmin Kim, Yonghwan Shin, Nikhil B Ghate, Woojin An · 2026
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Description
Sungmin Kim, Yonghwan Shin, Nikhil Ghate, and Woojin An present a stronger blocker of a bone-eating process. Their 2026 paper targets a kinase called VprBP, which helps precursor cells turn into osteoclasts, the cells that resorb bone. Too much of that turn drives bone loss disease. Their first blocker was too weak for real use.
They built a series of variants and screened them for power. Three blocked the kinase and slowed precursor change in lab tests. Across dose ranges, one compound, B1486, proved the most potent. In fish and mouse models, it cut bone resorption and eased low bone mass. The authors call it a second-generation lead for diseases of excess bone loss, with a clear edge over their first compound.
Catalog record
| CREATOR | Sungmin Kim, Yonghwan Shin, Nikhil B Ghate, Woojin An |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |