Mammalian DNA methyltransferases in DNA methylation and imprinted gene expression in extraembryonic ectoderm of post-implantation embryos
Ting Lu, Yilin Li, Yuping Wen, Zhen Xu, Haodong Lin, Guofeng Shao, Xiajun Li · 2026
Read Mammalian DNA methyltransferases in DNA methylation and imprinted gene expression in extraembryonic ectoderm of post-implantation embryos by Ting Lu, Yilin Li, Yuping Wen, Zhen Xu, Haodong Lin, Guofeng Shao, Xiajun Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13671026.txt.
Description
Ting Lu and six co-authors present a 2026 study of DNA methylation in early mouse embryos. Methylation is a chemical mark that helps switch genes on or off. Three enzymes place the marks: DNMT1 keeps old marks, while DNMT3A and DNMT3B were thought to add new ones.
The team focused on the extraembryonic ectoderm, a tissue that helps form the placenta. There, the two DNMT3 enzymes also kept marks across the genome, not just at new sites. At some imprinted regions, all three enzymes guarded the marks. Losing the marks at a control site flipped which parent copy of a gene was used. The study widens the known role of the DNMT3 pair in early growth.
Catalog record
| CREATOR | Ting Lu, Yilin Li, Yuping Wen, Zhen Xu, Haodong Lin, Guofeng Shao, Xiajun Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |