Development of a pediatric pig model of extracorporeal cardiopulmonary resuscitation-induced acute kidney injury
Lindsay M Thomson, Christopher A Mancuso, Robert Hyslop, Ludmila Khailova, Camille N Chun, Jack Zakrzewski, Sierra S Niemiec, Tanner M Lehmann, Benjamin S Frank, Jesse A Davidson · 2026
Read Development of a pediatric pig model of extracorporeal cardiopulmonary resuscitation-induced acute kidney injury by Lindsay M Thomson, Christopher A Mancuso, Robert Hyslop, Ludmila Khailova, Camille N Chun, Jack Zakrzewski, Sierra S Niemiec, Tanner M Lehmann, Benjamin S Frank, Jesse A Davidson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13670352.txt.
Description
Lindsay M Thomson and colleagues present a two thousand twenty-six development of a young pig model for kidney injury after extracorporeal resuscitation. Restarting children's hearts with a heart-lung machine often damages kidneys, multiplying death risk. No faithful laboratory model existed to study mechanisms or treatments.
Infant pigs underwent controlled cardiac arrests of increasing length, then hours of machine support. Kidney damage in tissue, blood markers, and physiology deepened with arrest duration. Gene activity shifted across more than a thousand genes in stress and vessel pathways. The staged model now enables treatment testing.
Catalog record
| CREATOR | Lindsay M Thomson, Christopher A Mancuso, Robert Hyslop, Ludmila Khailova, Camille N Chun, Jack Zakrzewski, Sierra S Niemiec, Tanner M Lehmann, Benjamin S Frank, Jesse A Davidson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |