Comparative genomics reveals lineage‐associated structural variation and diversification in a barley fungal pathogen
Xiaohui Yu, Mumta Chhetri, Mafruha Hasan, Thomas H. Roberts, Peng Zhang, Robert F. Park, Yi Ding · 2026
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Description
Barley leaf rust keeps reinventing itself against farmers' defenses. Xiaohui Yu and co-authors read its genome to find how, in a 2026 study. They built complete genomes for two contrasting isolates and surveyed forty-one Australian isolates collected across fifty-four years.
One chromosome stood out as restless, shuffled by repeats and riddled with rearrangements that differ by lineage. Family lines split into clonal copiers and recombining mixers, with mating-type genes confirming the divide. Newer isolates carried more duplicated DNA. One gene, Cyp51, the target of common fungicides, appeared in extra copies in certain lineages, and extra copies spoke louder, a plausible route to drug failure. The authors tie the genome's shifting structure to the pathogen's knack for adaptation.
Catalog record
| CREATOR | Xiaohui Yu, Mumta Chhetri, Mafruha Hasan, Thomas H. Roberts, Peng Zhang, Robert F. Park, Yi Ding |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |