Oleanolic acid inhibits diet-induced adiposity through blocking neovascularization and macrophage accumulation involving Delta-like 4-Notch 1-nuclear factor-κB signaling
Sin-Hye Park, Eunkyeong Kim, Young-Hee Kang · 2026
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Description
Sin-Hye Park, Eunkyeong Kim, and Young-Hee Kang test a plant acid against diet-driven fat in this 2026 study. Growing fat tissue needs new blood vessels, and oxygen-starved fat draws immune cells that fan inflammation. Mice on a high-fat diet got daily oleanolic acid for twenty weeks.
Treated mice gained less weight and fat, with smaller fat cells. Vessel growth signals in fat fell, harmful oxygen species dropped, and immune cell entry eased. A notch pathway tied to vessel sprouting and inflammation was blocked along the way. The authors present the acid as a candidate therapy for diet-driven obesity.
Catalog record
| CREATOR | Sin-Hye Park, Eunkyeong Kim, Young-Hee Kang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |