Regulation of PDH via cysteine oxidation on DLAT
Fabiola Garcia-Cortizo, Tobias Weber, Hana Nůsková, Daniel Pfaff, Michael Büttner, Angela Wirth, Elisabeth Kliemank, Gernot Poschet, Marc Freichel, Thomas Fleming, Alba Sulaj, Peter Paul Nawroth, Julia Szendroedi, Aurelio A. Teleman · 2026
Read Regulation of PDH via cysteine oxidation on DLAT by Fabiola Garcia-Cortizo, Tobias Weber, Hana Nůsková, Daniel Pfaff, Michael Büttner, Angela Wirth, Elisabeth Kliemank, Gernot Poschet, Marc Freichel, Thomas Fleming, Alba Sulaj, Peter Paul Nawroth, Julia Szendroedi, Aurelio A. Teleman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13669365.txt.
Description
Fabiola Garcia-Cortizo and thirteen colleagues discovered a second, chemical way cells switch off a central metabolic enzyme. The pyruvate dehydrogenase complex gates carbon flow from sugar breakdown into the cell's main energy cycle. It was known to be controlled by phosphorylation. The team found that oxidation of three cysteines on its DLAT subunit also inhibits it. This oxidation rises under oxidative stress and is common in mouse and human tissues.
Blocking the complex reroutes sugar carbons into a pathway that makes NADPH, the cell's antioxidant currency. Mutant enzymes that cannot be oxidized broke this defense: cells made less NADPH, detoxified peroxide poorly, and suffered more damage. The twenty twenty-six study reframes a textbook enzyme as a redox sensor wired into stress survival.
Catalog record
| CREATOR | Fabiola Garcia-Cortizo, Tobias Weber, Hana Nůsková, Daniel Pfaff, Michael Büttner, Angela Wirth, Elisabeth Kliemank, Gernot Poschet, Marc Freichel, Thomas Fleming, Alba Sulaj, Peter Paul Nawroth, Julia Szendroedi, Aurelio A. Teleman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |