Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium
Afzaal N Mohammed, Zicheng Deng, Arnab Misra, Marcus Orzabal, Ananya Kondapally, Enhong Li, Jonathan Do, Ying‐Wei Lan, Fatemeh Kohram, Hunter Blackburn, Andreas Damianos, Tanya V Kalin, Vladimir V Kalinichenko · 2026
Read Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium by Afzaal N Mohammed, Zicheng Deng, Arnab Misra, Marcus Orzabal, Ananya Kondapally, Enhong Li, Jonathan Do, Ying‐Wei Lan, Fatemeh Kohram, Hunter Blackburn, Andreas Damianos, Tanya V Kalin, Vladimir V Kalinichenko (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13669217.txt.
Description
Afzaal Mohammed and a large team build a nanoparticle system that delivers drugs to the lung's inner lining, in this 2026 Europe PMC paper. Pediatric acute respiratory distress syndrome damages lung endothelial cells and carries high mortality, yet precise delivery to the pulmonary vasculature is hard. A protein called FOXF1, key to vessel growth and repair, drops in the disease.
Their Lung Endothelial Drug Delivery particles carry a new compound that prevents FOXF1 breakdown, restoring its levels only in lung endothelial cells. In a mouse model, treatment was non-toxic, improved survival, reduced vessel leakiness and aided repair and air sac development. The system is offered as a versatile platform for lung-targeted therapy.
Catalog record
| CREATOR | Afzaal N Mohammed, Zicheng Deng, Arnab Misra, Marcus Orzabal, Ananya Kondapally, Enhong Li, Jonathan Do, Ying‐Wei Lan, Fatemeh Kohram, Hunter Blackburn, Andreas Damianos, Tanya V Kalin, Vladimir V Kalinichenko |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |