Single-cell Transcriptomics in Autoimmune Diseases: Mechanistic Insights, Cross-disease Convergence, and Translational Challenges in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Type 1 Diabetes, and Multiple Sclerosis
Thanh-Hong Nguyen, Tuan-Dinh Nguyen, Oanh-Thi Hoang, Thuy-Thu T Can, Minh-Huyen T Nguyen, Mai-Hoang Tran, Hieu-Chi Chu, Dinh-Van Nguyen · 2026
Read Single-cell Transcriptomics in Autoimmune Diseases: Mechanistic Insights, Cross-disease Convergence, and Translational Challenges in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Type 1 Diabetes, and Multiple Sclerosis by Thanh-Hong Nguyen, Tuan-Dinh Nguyen, Oanh-Thi Hoang, Thuy-Thu T Can, Minh-Huyen T Nguyen, Mai-Hoang Tran, Hieu-Chi Chu, Dinh-Van Nguyen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13669051.txt.
Description
Thanh-Hong Nguyen and co-authors review single cell studies across four autoimmune diseases in a 2026 paper. Bulk gene studies blur the rare cell states that may drive disease. Single cell methods profile each cell's activity one by one. The review checks arthritis, lupus, type one diabetes, and multiple sclerosis side by side.
Shared flare signals appeared across the diseases, led by alarm pathways. Deeper sameness at the cell state level, though, stayed thinly proven. Many findings rest on single snapshots rather than follow up over time. The authors sort solid results from early hints for future work.
Catalog record
| CREATOR | Thanh-Hong Nguyen, Tuan-Dinh Nguyen, Oanh-Thi Hoang, Thuy-Thu T Can, Minh-Huyen T Nguyen, Mai-Hoang Tran, Hieu-Chi Chu, Dinh-Van Nguyen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |