Aberrant excitatory neuronal ERBB4 promotes Alzheimer’s disease pathology
Se Young Lee, Eunseok Park, Ha-Eun Lee, Seongbin Kim, Yeji Yeo, Juwon Park, Young-Jin Choi, Kiheon Lee, Ki-Jun Yoon, Sanghoon Park, Eunjoon Kim, Jae-Ick Kim, Won-Suk Chung · 2026
Read Aberrant excitatory neuronal ERBB4 promotes Alzheimer’s disease pathology by Se Young Lee, Eunseok Park, Ha-Eun Lee, Seongbin Kim, Yeji Yeo, Juwon Park, Young-Jin Choi, Kiheon Lee, Ki-Jun Yoon, Sanghoon Park, Eunjoon Kim, Jae-Ick Kim, Won-Suk Chung (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13668712.txt.
Description
Se Young Lee and a team of co-authors identified an early driver of Alzheimer's disease in a 2026 study of mice and human data. Loss of synapses and brain inflammation track with the memory decline of the disease, yet the chain of causes stays murky. The team found a small set of excited neurons that switch on a gene called Erbb4 early in the disease course.
Removing that gene only from those neurons stopped abnormal firing, synapse loss, inflammation, plaque buildup, and memory problems in the mice. Adding the gene to healthy neurons copied much of the disease pattern, even without plaques. The effect ran through a known growth signal path. Human brain data fit the same chain, which links plaques to later tau spread and decline. The authors name the gene as a possible early target.
Catalog record
| CREATOR | Se Young Lee, Eunseok Park, Ha-Eun Lee, Seongbin Kim, Yeji Yeo, Juwon Park, Young-Jin Choi, Kiheon Lee, Ki-Jun Yoon, Sanghoon Park, Eunjoon Kim, Jae-Ick Kim, Won-Suk Chung |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 100 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |