Intracellular complement factor H protects neurons during CNS inflammation
Christina Mayer, Marcel S. Woo, Jana K. Sonner, Lars Binkle-Ladisch, Felix Fischbach, Patricia Sekol, Matthew D. Smith, Fernando Lucas-Ruiz, Darwin Manteufel, Kuno M.-J. Mattern, Lena Kristina Pfeffer, Yubing Guo, Bente Siebels, Albert Miguela, Vanessa Vieira, Nina Meurs, Simone Bauer, Sophia Schwar · 2026
Read Intracellular complement factor H protects neurons during CNS inflammation by Christina Mayer, Marcel S. Woo, Jana K. Sonner, Lars Binkle-Ladisch, Felix Fischbach, Patricia Sekol, Matthew D. Smith, Fernando Lucas-Ruiz, Darwin Manteufel, Kuno M.-J. Mattern, Lena Kristina Pfeffer, Yubing Guo, Bente Siebels, Albert Miguela, Vanessa Vieira, Nina Meurs, Simone Bauer, Sophia Schwar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13668678.txt.
Description
Christina Mayer leads a large team in this 2026 study on why some nerve cells survive the inflammation of multiple sclerosis. The disease slowly destroys nerve cells, and eye nerve cells offer a clear window on that loss. Reading gene activity cell by cell in donor tissue, the team found one factor stood out in the cells that held up best: complement factor H.
That factor is best known for policing the immune system outside cells. Inside neurons, the team found, it does a different job. Stress switches it on, and it curbs the buildup of harmful oxygen byproducts and fat damage at the cell's protein-making membranes. Its shield work needed one tail domain but not its usual immune partners. The finding held across brain regions and species. It points to a built-in defense that future MS treatments might strengthen.
Catalog record
| CREATOR | Christina Mayer, Marcel S. Woo, Jana K. Sonner, Lars Binkle-Ladisch, Felix Fischbach, Patricia Sekol, Matthew D. Smith, Fernando Lucas-Ruiz, Darwin Manteufel, Kuno M.-J. Mattern, Lena Kristina Pfeffer, Yubing Guo, Bente Siebels, Albert Miguela, Vanessa Vieira, Nina Meurs, Simone Bauer, Sophia Schwar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 104 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |