Ketone homologation via palladium-catalysed decarboxylative rearrangement
Jing Gong, Qian Wang, Jieping Zhu · 2026
Read Ketone homologation via palladium-catalysed decarboxylative rearrangement by Jing Gong, Qian Wang, Jieping Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13668645.txt.
Description
A classic rearrangement reaction gains precise stereo control under palladium, Jing Gong, Qian Wang, and Jieping Zhu report in a 2026 study. Stretching a ketone by one carbon through this route once ran through wild radical steps that scrambled the product's handedness. The new version runs through a closed six-membered palladium ring instead.
Carbon dioxide leaves as one carbon hops from one position to the next. The hopping carbon keeps its handedness while its neighbor flips. For lopsided ketones, the choice of which group hops beats two classic named reactions. A broad range of rings can be built this way with reliable shape.
Catalog record
| CREATOR | Jing Gong, Qian Wang, Jieping Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |