Single-nuclei transcriptomics reveals cellular senescence in pediatric anthracycline-induced cardiomyopathy
Diwakar Turaga, Chang-Ru Tsai, Yuka Morikawa, Hanna J Tadros, Yi Zhao, Lalita Wadhwa, Iki Adachi, Xiao Li, James F Martin · 2026
Read Single-nuclei transcriptomics reveals cellular senescence in pediatric anthracycline-induced cardiomyopathy by Diwakar Turaga, Chang-Ru Tsai, Yuka Morikawa, Hanna J Tadros, Yi Zhao, Lalita Wadhwa, Iki Adachi, Xiao Li, James F Martin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13668626.txt.
Description
Diwakar Turaga and co-authors find aged heart cells in treated children in a 2026 study. Anthracycline drugs cure many childhood cancers but can damage young hearts. Some children later develop heart failure from that early treatment.
Single-nuclei transcriptomics reads gene activity cell by cell in heart tissue. The team found cellular senescence, a worn-out aging state, spread across those hearts. Senescent cells stop dividing yet stir inflammation around them. That spread may explain why damage grows years after treatment ends. Naming the aging process opens paths to drugs that clear or calm those cells.
Catalog record
| CREATOR | Diwakar Turaga, Chang-Ru Tsai, Yuka Morikawa, Hanna J Tadros, Yi Zhao, Lalita Wadhwa, Iki Adachi, Xiao Li, James F Martin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |