Microglial GRB2 is essential for brain ventriculogenesis and cerebrospinal fluid homeostasis
Phan Q. Duy, Benjamin C. Reeves, Huanxing Sun, Xueyan Peng, Pazhanichamy Kalailingam, Garrett Allington, Evan Dennis, Le Thi Hao, Lei Wang, David Rufino-Ramos, Shujuan Zhao, Qiang Li, Neel H. Mehta, William C. Davalan, Mason Blacker, Anthony J. Piscopo, Shozeb Haider, Baojian Fan, Kedous Y. Mekbib, · 2026
Read Microglial GRB2 is essential for brain ventriculogenesis and cerebrospinal fluid homeostasis by Phan Q. Duy, Benjamin C. Reeves, Huanxing Sun, Xueyan Peng, Pazhanichamy Kalailingam, Garrett Allington, Evan Dennis, Le Thi Hao, Lei Wang, David Rufino-Ramos, Shujuan Zhao, Qiang Li, Neel H. Mehta, William C. Davalan, Mason Blacker, Anthony J. Piscopo, Shozeb Haider, Baojian Fan, Kedous Y. Mekbib, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13668624.txt.
Description
Phan Duy and many co-authors (2026) link a gene carried by microglia to congenital hydrocephalus. Microglia are the brain's immune cells. In this condition, fluid builds up and enlarges the brain's ventricles in infants. It is a leading reason for brain surgery in children, yet its causes are poorly understood. The team found recurring damaging changes in GRB2, a gene for an adaptor protein, in unrelated patients. The changes cluster in one binding region of the protein.
In the developing brain, GRB2 is co-expressed with its partner receptor, CSF1R. This happens especially in a subtype of microglia. The study shows these cells are needed for the ventricles to form properly. They also keep the brain's fluid in balance. The findings recast a condition long treated as a plumbing problem. At least in part, it is a disorder of brain immune cells during development.
Catalog record
| CREATOR | Phan Q. Duy, Benjamin C. Reeves, Huanxing Sun, Xueyan Peng, Pazhanichamy Kalailingam, Garrett Allington, Evan Dennis, Le Thi Hao, Lei Wang, David Rufino-Ramos, Shujuan Zhao, Qiang Li, Neel H. Mehta, William C. Davalan, Mason Blacker, Anthony J. Piscopo, Shozeb Haider, Baojian Fan, Kedous Y. Mekbib, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |