Local control of Cre-regulated genetic modeling in vivo using wireless implantable optoelectronics
Trisha Bansal, Min-Kyu Lee, Courtney Coleman, Young-Mee Kim, Dane Hintermueller, Yaner Chen, Varsha Sreekanth, Chad R. Haney, Olga A. Karginova, Raudel Avila, Jacob Matsche, Shaluah Vijeth, Farah Yousef, Kento Yamagishi, Jiheon Kang, Kaitlyn Mowry, Minsung Kim, Sophianne Loh, Sachin Clark, Huong Huy · 2026
Read Local control of Cre-regulated genetic modeling in vivo using wireless implantable optoelectronics by Trisha Bansal, Min-Kyu Lee, Courtney Coleman, Young-Mee Kim, Dane Hintermueller, Yaner Chen, Varsha Sreekanth, Chad R. Haney, Olga A. Karginova, Raudel Avila, Jacob Matsche, Shaluah Vijeth, Farah Yousef, Kento Yamagishi, Jiheon Kang, Kaitlyn Mowry, Minsung Kim, Sophianne Loh, Sachin Clark, Huong Huy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13665946.txt.
Description
Turning genes on in one patch of a living organ takes light delivered exactly there, without waking the gene elsewhere. Trisha Bansal and co-authors built that control for mouse lungs in a 2026 paper. Their switch is a light-driven gene editor that stays fully off in the dark. Wireless implants, small enough to sit inside the body, shine blue light on chosen lung spots. Brighter or longer light widens the activated patch.
Lung tissue showed no clear damage from the implants. Genes in the lit zone switched on while the rest stayed quiet. The team frames the tool for modeling chronic human disease in place. Implant design and switch design advance together in the work.
Catalog record
| CREATOR | Trisha Bansal, Min-Kyu Lee, Courtney Coleman, Young-Mee Kim, Dane Hintermueller, Yaner Chen, Varsha Sreekanth, Chad R. Haney, Olga A. Karginova, Raudel Avila, Jacob Matsche, Shaluah Vijeth, Farah Yousef, Kento Yamagishi, Jiheon Kang, Kaitlyn Mowry, Minsung Kim, Sophianne Loh, Sachin Clark, Huong Huy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 112 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |