Mitochondrial carbonic anhydrase–VB inhibition rescues brain endothelial stress and memory in Alzheimer’s disease models
Nicole L. Lemon, Elisa Canepa, Rafael Vázquez-Torres, Rebecca Parodi-Rullán, Tina Hirt, Lisa M. Petersohn, Tashnuva Rifat, Maryam H. Abyaneh, Marc A. Ilies, Silvia Fossati · 2026
Read Mitochondrial carbonic anhydrase–VB inhibition rescues brain endothelial stress and memory in Alzheimer’s disease models by Nicole L. Lemon, Elisa Canepa, Rafael Vázquez-Torres, Rebecca Parodi-Rullán, Tina Hirt, Lisa M. Petersohn, Tashnuva Rifat, Maryam H. Abyaneh, Marc A. Ilies, Silvia Fossati (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13665925.txt.
Description
Ten researchers target a mitochondrial enzyme to protect the brain in Alzheimer's models in a 2026 paper. Alzheimer's disease brings amyloid and tau build up with no effective cure, and vessel and mitochondria failure arrive early. Earlier work hinted that blocking carbonic anhydrases guards both systems.
The team blocked the mitochondrial form, CA-VB, with drugs and gene knockout in human brain vessel cells. The block prevented amyloid driven cell death, barrier loss, and inflammatory activation. In triple transgenic Alzheimer's mice, treatment calmed cell death signals and vessel activation in the brain. Memory stayed preserved in the treated animals. The authors propose selective CA-V blockade as a strategy against vessel driven disease.
Catalog record
| CREATOR | Nicole L. Lemon, Elisa Canepa, Rafael Vázquez-Torres, Rebecca Parodi-Rullán, Tina Hirt, Lisa M. Petersohn, Tashnuva Rifat, Maryam H. Abyaneh, Marc A. Ilies, Silvia Fossati |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |