Triokinase/FMN Cyclase: A Bifunctional Enzyme Linking Metabolism, Stress Responses and Disease
João Meireles Ribeiro, Fernando Martín-Ruiz, José Carlos Cameselle · 2026
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Description
João Meireles Ribeiro, Fernando Martín-Ruiz, and José Carlos Cameselle review a two-job enzyme linking sugar and vitamin chemistry, in a 2026 paper. The enzyme both phosphorylates triose sugars and makes a cyclic flavin compound. One protein thus joins fructose handling with riboflavin chemistry. Structure models show a two-part dimer. Its active sites sit between the parts and serve both reactions. The enzyme steers where fructose carbon goes in the cell.
Newer work ties it to nutrient sensing and stress defense. It also touches innate immunity and a cell death pathway. Several inherited disorders involve it. The cyclic flavin product is now treated as a real metabolite. Its breakdown and turnover remain unsettled. The review covers the enzyme's history, structure, and mechanisms. Expanding roles in disease take the final sections. The authors see it as an underappreciated metabolic hub.
Catalog record
| CREATOR | João Meireles Ribeiro, Fernando Martín-Ruiz, José Carlos Cameselle |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |