Longitudinal Changes in Testicular Volume and the Additional Value of Body Weight for Estimating Histology-Linked Testicular Development in Male Cynomolgus Macaques (Macaca fascicularis)
Ryosuke Kawashima, Hirofumi Matsumoto, Atsushi Asano · 2026
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Description
Toxicology studies in macaques need males at a known stage of testicular maturity, and age alone is a sloppy guide. Ryosuke Kawashima, Hirofumi Matsumoto, and Atsushi Asano mined two decades of colony records: over thirty-one thousand observations from more than twenty-two thousand cynomolgus monkeys of Chinese and Cambodian origin. Volume rose steeply between four and six years of age.
At five years, only about half the animals had crossed the volume threshold tied to mature tissue, whichever their origin. Body weight added real information on top of age. The authors recommend measuring directly, with weight as a cheap supporting clue for screening.
Catalog record
| CREATOR | Ryosuke Kawashima, Hirofumi Matsumoto, Atsushi Asano |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |