Reply to “Methodological caveats in interpreting slow-wave slope as a marker of synaptic homeostasis in OSA”
Rama Maganti, Jun Wang, Scott Hetzel · 2026
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Description
Rama Maganti and co-authors reply to critics of their sleep study in a 2026 letter. The study used brain wave records to track deep sleep in people with sleep apnea. Critics warned that one brain wave measure may not show cell level sleep pressure alone. They also raised worries about a floor effect and a math flaw in the slope measure.
The authors agree the brain wave sign is not a pure marker and note missing brain scans as a limit. They reject the floor effect claim with group data that sit far above zero. They also explain how the slope was built hour by hour for each person. Their view is that the flat overnight pattern still points to weak sleep pressure build up.
Catalog record
| CREATOR | Rama Maganti, Jun Wang, Scott Hetzel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 5 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |