Comparative Efficacy and Safety of Systemic Immunomodulatory Therapies for Non‐Infectious Uveitis: A Systematic Review With Pairwise and Network Meta‐Analyses
Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan · 2026
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Description
Chen, Chan, and Chan reviewed the drug treatments that calm immune attack inside the eye, in a systematic review published in 2026. The disease, non-infectious uveitis, is a chronic inflammation that can blind if untreated. Steroids cannot be used forever, so immune-suppressing drugs, old and biologic, carry the long-term load. Head-to-head trials are rare, leaving doctors unsure which drug wins. The team searched four major databases for trials and prospective comparisons.
They combined the studies two ways: direct pairwise pooling, and a network method that links drugs through shared comparators. Outcomes weighed both inflammation control and side effects. The synthesis ranks the options on current evidence. For a blinding disease with many contenders, such a ranking guides real prescriptions. It also exposes where trials are missing, which shapes the next studies worth funding.
Catalog record
| CREATOR | Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |