Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles
Dengpan Liang, Yalin Qi, Hesong Han, Negar Ahmadian, Kewa Gao, Kaycee Sapasap, Yuxi Zhang, Silin Guo, Atip Lawanprasert, Sopida Pimcharoen, Sheng Zhao, Milan T Del Buono, He Xia, Zoe O Enders, Benjamin W Burgstone, Antonino Calio, Neel Dankar, Bingwei Lu, Lei S Qi, Aijun Wang, Niren Murthy · 2026
Read Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles by Dengpan Liang, Yalin Qi, Hesong Han, Negar Ahmadian, Kewa Gao, Kaycee Sapasap, Yuxi Zhang, Silin Guo, Atip Lawanprasert, Sopida Pimcharoen, Sheng Zhao, Milan T Del Buono, He Xia, Zoe O Enders, Benjamin W Burgstone, Antonino Calio, Neel Dankar, Bingwei Lu, Lei S Qi, Aijun Wang, Niren Murthy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13661284.txt.
Description
Dengpan Liang and colleagues present a two thousand twenty-six study on safer fat particles for delivering genetic medicine. Lipid nanoparticles carry nucleic acids well, but they provoke inflammation. The same features that cause harm also enable delivery, which makes redesign hard.
The team built fats that switch charge as acidity changes between blood and cell compartments. The new particles loaded cargo and released it inside cells. They did so without triggering several inflammatory pathways that standard particles activate. In mice with lung injury, the new particles treated the condition without worsening existing inflammation. Drug designers get a route to gentler carriers.
Catalog record
| CREATOR | Dengpan Liang, Yalin Qi, Hesong Han, Negar Ahmadian, Kewa Gao, Kaycee Sapasap, Yuxi Zhang, Silin Guo, Atip Lawanprasert, Sopida Pimcharoen, Sheng Zhao, Milan T Del Buono, He Xia, Zoe O Enders, Benjamin W Burgstone, Antonino Calio, Neel Dankar, Bingwei Lu, Lei S Qi, Aijun Wang, Niren Murthy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |