DFCP1-containing ER microdomains mediate lysosomal membrane repair
Maja Radulovic, Sascha Pust, Athanasios Kournoutis, Di Chen, M Isabel Giner, Qijian Liang, Santosh Phuyal, Thomas J Böddeker, Katy McCarron, Eric Herrmann, Kevin Rose, Sebastian W Schultz, Andreas Brech, James H Hurley, Claudio Bussi, Luis Bonet-Ponce, Maximiliano G Gutierrez, Camilla Raiborg, Haral · 2026
Read DFCP1-containing ER microdomains mediate lysosomal membrane repair by Maja Radulovic, Sascha Pust, Athanasios Kournoutis, Di Chen, M Isabel Giner, Qijian Liang, Santosh Phuyal, Thomas J Böddeker, Katy McCarron, Eric Herrmann, Kevin Rose, Sebastian W Schultz, Andreas Brech, James H Hurley, Claudio Bussi, Luis Bonet-Ponce, Maximiliano G Gutierrez, Camilla Raiborg, Haral (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13661268.txt.
Description
Maja Radulovic and co-authors (2026) uncover a repair crew that patches damaged lysosomes, the cell's recycling sacs. A torn lysosome leaks enzymes that can digest the cell from inside, so membranes must be resealed fast. Cells run several repair routes, including a lipid supply line from the endoplasmic reticulum, the cell's membrane factory. How that supply is switched on was unclear. The team shows that small regions of the reticulum, marked by a fat molecule called PI3P and the protein DFCP1, do the job.
When a lysosome is damaged, an enzyme on nearby reticulum domains makes PI3P on the spot. Blocking that enzyme, PIK3C3, or removing it, cripples the repair. These microdomains sit against the wounded lysosome and feed it lipids to close the breach. The finding orders a crowded field: it names the reticulum patch that answers first when the recycling system springs a leak.
Catalog record
| CREATOR | Maja Radulovic, Sascha Pust, Athanasios Kournoutis, Di Chen, M Isabel Giner, Qijian Liang, Santosh Phuyal, Thomas J Böddeker, Katy McCarron, Eric Herrmann, Kevin Rose, Sebastian W Schultz, Andreas Brech, James H Hurley, Claudio Bussi, Luis Bonet-Ponce, Maximiliano G Gutierrez, Camilla Raiborg, Haral |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 121 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |