A step-wise, deterministic and fatal mouse model of myeloid neoplasm with spontaneous acquisition of patient-relevant RTK–RAS mutations
Marija A Zarocsinceva, Moosa Qureshi, Nicola K Wilson, George Giotopoulos, Blaise Musabe, Katherine H M Sturgess, M S Vijayabaskar, Sarah J Kinston, Ryan Asby, David J Adams, Brian J P Huntly, Fernando J Calero-Nieto, Berthold Göttgens · 2026
Read A step-wise, deterministic and fatal mouse model of myeloid neoplasm with spontaneous acquisition of patient-relevant RTK–RAS mutations by Marija A Zarocsinceva, Moosa Qureshi, Nicola K Wilson, George Giotopoulos, Blaise Musabe, Katherine H M Sturgess, M S Vijayabaskar, Sarah J Kinston, Ryan Asby, David J Adams, Brian J P Huntly, Fernando J Calero-Nieto, Berthold Göttgens (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13661246.txt.
Description
Marija Zarocsinceva and co-authors build a mouse model that replays how a blood cancer grows from a silent first step. Leukemia starts when a healthy blood-forming cell picks up a founding change and sits quiet for a long time before further changes tip it into disease. The team placed a patient-derived founding change into mouse blood stem cells and transplanted them into healthy mice.
Every recipient stayed well for about a year, then developed disease, and every tumor had gained extra changes in the same growth-signaling pathway seen in patients, often the identical letter swaps. Cell-by-cell reading showed the quiet cells kept making several blood lineages before each tumor settled on one. The authors offer the model for studying the silent phase and testing drugs.
Catalog record
| CREATOR | Marija A Zarocsinceva, Moosa Qureshi, Nicola K Wilson, George Giotopoulos, Blaise Musabe, Katherine H M Sturgess, M S Vijayabaskar, Sarah J Kinston, Ryan Asby, David J Adams, Brian J P Huntly, Fernando J Calero-Nieto, Berthold Göttgens |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |