Multi-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis
Wenlong Li, Muntadher Jihad, Eloise G Lloyd, Marta Zaccaria, Gianluca Mucciolo, Gideon Nsubuga, Alwin Koonan-Lonappan, Joaquín Araos Henríquez, Priscilla S W Cheng, Sneha Harish, Sally Mills, Paul M Johnson, Weike Luo, Alejandro Alonso Montero, Rebecca Brais, Alex Deamer, Ania M Piskorz, Julia Jones · 2026
Read Multi-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis by Wenlong Li, Muntadher Jihad, Eloise G Lloyd, Marta Zaccaria, Gianluca Mucciolo, Gideon Nsubuga, Alwin Koonan-Lonappan, Joaquín Araos Henríquez, Priscilla S W Cheng, Sneha Harish, Sally Mills, Paul M Johnson, Weike Luo, Alejandro Alonso Montero, Rebecca Brais, Alex Deamer, Ania M Piskorz, Julia Jones (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13661236.txt.
Description
Wenlong Li and a large team compare fibroblast diversity in pancreatic cancer and chronic pancreatitis, in work published in 2026. How tumor-supporting fibroblasts differ from those in inflamed pancreas tissue is unclear, yet the gap matters for treatment response. The team used human samples, mouse models and organoids grown from pancreatitis tissue, then built co-cultures mixing organoids with stellate cells, fibroblasts and mesothelial cells.
Cancer and inflammation showed distinct epithelial and fibroblast features rather than one shared stromal pattern. Mixing lab and animal models mirrored human disease better than mouse models alone. The platform is offered as a way to find disease-specific markers and weak points for therapy.
Catalog record
| CREATOR | Wenlong Li, Muntadher Jihad, Eloise G Lloyd, Marta Zaccaria, Gianluca Mucciolo, Gideon Nsubuga, Alwin Koonan-Lonappan, Joaquín Araos Henríquez, Priscilla S W Cheng, Sneha Harish, Sally Mills, Paul M Johnson, Weike Luo, Alejandro Alonso Montero, Rebecca Brais, Alex Deamer, Ania M Piskorz, Julia Jones |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 156 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |