Phospholipase A2 enhances the cytotoxic activity of membranolytic peptide Polybia MP1 in some breast epithelial cells
Arindam Pramanik, Dapeng Wang, Dagmara Kobza, Lewis P Reed, Paul A Beales, Thomas A Hughes · 2026
Read Phospholipase A2 enhances the cytotoxic activity of membranolytic peptide Polybia MP1 in some breast epithelial cells by Arindam Pramanik, Dapeng Wang, Dagmara Kobza, Lewis P Reed, Paul A Beales, Thomas A Hughes (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13661229.txt.
Description
Pramanik and co-authors study MP1, a wasp-venom peptide that punches holes in cell membranes, and ask why some cancer cells die from it while others resist. Across 64 cancer cell lines, killing power varied more than eightfold: blood cancers were most sensitive, bowel cancers most resistant, and breast lines scattered widest.
Gene activity pointed at fat-cutting enzymes. Adding one of them, phospholipase A2, did little on its own but sharply boosted MP1's killing in two of four breast cell lines, in step with the dose. The pair seems to attack some breast cancer membranes together. That pairing could shape how MP1-based therapies get developed.
Catalog record
| CREATOR | Arindam Pramanik, Dapeng Wang, Dagmara Kobza, Lewis P Reed, Paul A Beales, Thomas A Hughes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |